Written by Nurliyana Athirah Md Sidek
Published on Vol 1 , 2021
Engaging in physical activities such as exercise or sports often results in sweating, which is considered a healthy practice for promoting well-being. However, excessive sweating during daily life, especially when accompanied by unpleasant odors, can indicate poor hygiene and lead to discomfort and social problems. Deodorants and antiperspirants are commonly used to eliminate body odor, but their potential side effects have encouraged the search for natural alternatives. This study investigated
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Written by Ruth Goodluck Elefe
Published on Vol 1 , 2021
In recent times, there has been a growing interest in natural foods enriched with phenolic compounds and flavonoids due to their antioxidant properties. This study investigated the phenolic content of leaves from several plant species—Vernonia amygdalina, Mangifera indica, Dennettia tripetala, Azadirachta indica, Citrus sinensis, Chromolaena odorata, Anacardium occidentale, and Telfairia occidentalis—collected from southern Nigeria. Phenolic content was determined through absorbance readings at
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Written by Minyem Ngombi-Afuh Aude Périne
Published on Vol 1 , 2021
The use of Traditional Medicine (TM) has seen significant global growth. However, there is still a lack of understanding in areas such as regulation, legislation, and particularly homologation. The safety and effectiveness of TM have become pressing concerns for public health authorities. This study aims to assess the knowledge, attitudes, and practices related to the homologation of Improved Traditional Medicine (ITM) in Cameroon, specifically focusing on the Mfoundi division. The study surveye
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Written by Bushra Saad Alsahafi
Published on Vol 1 , 2021
Leptadenia pyrotechnica (Forssk.) Decne., a plant found predominantly in desert regions of Saudi Arabia, has demonstrated several therapeutic properties, including effects on the immune system. This study investigates how the aqueous extract of L. pyrotechnica affects immune function and body weight in rats. To date, there have been no published studies on the impact of L. pyrotechnica aqueous extract on immune responses and body weight. In this study, 72 adult Wistar albino rats were assigned t
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Written by Uchejeso Obeta
Published on Vol 1 , 2021
The popularity of Nigerian walnuts (Tetracarpidium conophorum) for dietary and medicinal purposes has surged, leading to a scarcity in the markets where they are sold. This study explores the walnut's classification, characteristics, phytochemical composition, nutritional value, and therapeutic properties. There is an increasing trend in research focused on leveraging Nigerian walnuts for drug development. The walnut has shown potential in areas such as antioxidant, anti-inflammatory, anti-c
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Written by Nguyen Van Minh
Published on Vol 1 , 2021
This study investigated the bioactive properties of Bacillus amyloliquefaciens RD26, an endophyte isolated from Phyllanthus amarus. The methanol extract of Bacillus sp. RD26 showed significant antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), with an inhibition zone of 25 ± 0.57 mm. The antibacterial compound, BR04, was isolated and identified as pyrimidine-2,4-dione (uracil), showing potent antimicrobial effects with minimum inhibitory concentrations (MICs) of 6
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Written by Melike Demir Doğan
Published on Vol 1 , 2021
This research aimed to investigate people's knowledge, perceptions, and personal experiences about menengic coffee and bittim soap. Data were collected from 152 participants living in Siirt and Mardin between June 1 and September 15, 2021, through internet-based methods (email, WhatsApp, Instagram, Facebook, etc.). Among those who use bittim soap or similar products, 16.4% reported daily usage. A significant portion (67.8%) of the participants consumed menengic coffee, with 46.7% acknowledgi
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Written by Hiroyuki Tanaka
Published on Vol 1 , 2021
Epilepsy ranks as the second most common neurological disorder worldwide, manifesting through recurrent, unprovoked, and self-limiting seizures that may have genetic, acquired, or unknown causes. This review focused on identifying pharmacogenomic markers linked to hypersensitivity reactions triggered by aromatic antiseizure medications. It addressed the pharmacokinetics and pharmacogenomics of CYP2C9 and HLA genes, explored immunopathogenic mechanisms, and discussed the clinical significance of
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Written by Stefan Müller
Published on Vol 1 , 2021
Patients with major depressive disorder (MDD) often face prolonged periods before achieving remission or a noticeable treatment response due to the trial-and-error nature of prescribing effective medications. Pharmacogenomic testing, which tailors drug selection based on genetic profiles, has demonstrated improvements in remission and response rates, yet its long-term effects remain unclear. This study aimed to investigate whether pharmacogenomic-guided therapy enhances remission and response ov
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ACE inhibitors (ACEIs) are a cornerstone in the treatment of hypertension and cardiovascular disorders, yet a notable side effect is dry cough, affecting roughly 5%–35% of patients and often resulting in treatment discontinuation. This study sought to uncover genetic variants that may predispose individuals to ACEI-related cough and to examine how these variants correlate with ACE enzyme levels in a multi-ethnic hypertensive cohort from the UAE. Participants were selected from the UAE-based EmHe
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Antipsychotic medications, commonly used to manage psychosis, often cause side effects that can range from mild to severe, and patients frequently require multiple medication trials to achieve an effective drug and dose. To address these challenges, there is growing interest in precision medicine approaches. Pharmacogenetics examines how individual genetic differences affect drug metabolism and therapeutic response. Recent clinical studies suggest that pharmacogenetic testing may help improve tr
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This study aimed to map Colombia’s pharmacogenomic (PGx) landscape with respect to ancestry by combining all PharmGKB variant-drug annotations with local allele-frequency data, in order to measure clinically relevant differences among ancestral groups and identify gaps that limit fair access to precision medicine. We analyzed 4,462 PharmGKB variant annotations spanning 1994–2024, narrowing the dataset to 1,216 significant single-nucleotide polymorphisms (SNPs) reported in 552 studies. Allele fre
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Written by Paolo Rinaldi
Published on Vol 1 , 2021
Drug hypersensitivity reactions (DHRs) remain a significant hurdle in psychiatric treatment, frequently causing therapy discontinuation, reduced adherence, and suboptimal clinical outcomes. Pharmacogenomics offers a powerful approach to unravel the genetic underpinnings that influence drug metabolism, immune system activation, and individual vulnerability to adverse reactions. This review provides a comprehensive overview of the diverse mechanisms behind DHRs, focusing on immune-mediated pathway
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Written by Hiroshi Nakamura
Published on Vol 1 , 2021
Aging arises from a complex convergence of inherited influences and lifelong environmental exposures, with epigenetic remodeling positioned at the core of this process. Disruptions in DNA methylation landscapes, altered activity of histone-modifying regulators such as SIRT1 and EZH2, and shifts in non-coding RNA pathways collectively rewire transcriptional programs that govern essential functions, including senescence control and mitochondrial integrity. These changes form a mechanistic “environ
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Written by Piotr Malinowski
Published on Vol 1 , 2021
Schizophrenia is a multifactorial neuropsychiatric disorder arising from a combination of neurochemical imbalances, genetic and epigenetic influences, environmental exposures, and other non-genetic factors. The field of pharmacoepigenetics examines how epigenetic variations influence an individual’s response to medications. This review aimed to provide a descriptive synthesis of current insights into the epigenetic regulation of pharmacogenes encoding metabolizing enzymes involved in the process
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