Coronary artery disease (CAD) remains one of the leading causes of mortality worldwide, and conventional therapies, such as percutaneous coronary intervention (PCI), have inherent limitations. This review focuses on examining the potential role of nanoparticles loaded with Chinese medicine in CAD treatment. A comprehensive literature search was conducted to summarize the properties of nanovehicle systems, targeting mechanisms, and administration routes for various nanoparticles carrying Chinese medicine in the context of CAD therapy. Nanoparticle-based drug delivery platforms provide several advantages, including enhanced targeting efficiency, extended circulation time, and reduced systemic toxicity, highlighting their promise for CAD management. In summary, Chinese medicine-loaded nanoparticles represent a novel and promising strategy for treating CAD.
