We'd appreciate your feedback. Send feedback Subscribe to our newsletters and alerts


Asian Journal of Current Research in Clinical Cancer

2024 Volume 4 Issue 2

Theoretical Model of Thiophene and Its Derivatives Interaction with BRCA-1


, , , , ,
  1. Pharmacochemistry Research Laboratory, Faculty of BiologicalChemical Sciences, University Autonomous of Campeche; Humberto Lanz Cárdenas s/n, Ex Hacienda Kalá, C.P., Campeche, Mexico.

  2. Nutrition Laboratory, Faculty of Nutrition, University of Veracruz, Medicos y s/n Odontologos 910210, Unidad del Bosque, Xalapa, Mexico.

Abstract

Research indicates a growing association between breast cancer and increased mortality rates across the globe. Various risk factors, such as obesity, high-fat diets, lack of physical exercise, alcohol use, oral contraceptive consumption, genetic mutations, and others, contribute to the development of breast cancer. In addition, some studies have pointed to the role of the breast cancer gene 1 (BRCA1) in breast cancer onset. The objective of this study was to investigate how thiophene (1) and its derivatives (2 to 25) interact with BRCA-1, using the 3pxb protein and niraparib as control compounds in a docking simulation. The results showed changes in the interaction of thiophene and its analogs with the 3pxb protein surface when compared to the niraparib drug. In addition, the inhibition constants (Ki) of thiophene-derivative-protein complexes for compounds 11, 13, 16, 18, and 20 showed similar patterns to that of niraparib. These findings suggest that these specific compounds may inhibit the activity of BRCA-1, which could lead to a reduction of breast cancer cell proliferation.


How to cite this article
Vancouver
FigueroaValverde L, Marcela RN, AlvarezRamirez M, Lopez-Ramos M, MateuArmand V, Patricia HV. Theoretical Model of Thiophene and Its Derivatives Interaction with BRCA-1. Asian J Curr Res Clin Cancer. 2024;4(2):43-50. https://doi.org/10.51847/rHeEej44vt
APA
FigueroaValverde, L., Marcela, R. N., AlvarezRamirez, M., Lopez-Ramos, M., MateuArmand, V., & Patricia, H. V. (2024). Theoretical Model of Thiophene and Its Derivatives Interaction with BRCA-1. Asian Journal of Current Research in Clinical Cancer, 4(2), 43-50. https://doi.org/10.51847/rHeEej44vt
Articles
Tolerability of Chemoradiotherapy in Geriatric Patients with Pancreatic Cancer
Asian Journal of Current Research in Clinical Cancer
Vol 5 Issue 1, 2025 | İrem Sarıcanbaz
Environmental Impact of the Y-Isomer of HCH: Unveiling Its Role in Cancer Formation
Asian Journal of Current Research in Clinical Cancer
Vol 2 Issue 2, 2022 | Mata Uvaysovna Razhaeva
An Overview of Targeted Therapy Applications in Cancer Treatment
Asian Journal of Current Research in Clinical Cancer
Vol 5 Issue 1, 2025 | Yeuan Ting Lee
Exploring Advanced Diagnostic Techniques for Salivary Gland Disorders: A Narrative Overview
Asian Journal of Current Research in Clinical Cancer
Vol 4 Issue 1, 2024 | Chuan Xiang Li
Alternative Perspective on Cancer Based on the Interaction between Plasma Radiation and DNA
Asian Journal of Current Research in Clinical Cancer
Vol 2 Issue 1, 2022 | Mahmoud Mohamed Ahmed
Theoretical Model of Thiophene and Its Derivatives Interaction with BRCA-1
Asian Journal of Current Research in Clinical Cancer
Vol 4 Issue 2, 2024 | Lauro FigueroaValverde
Tolerability of Chemoradiotherapy in Geriatric Patients with Pancreatic Cancer
Asian Journal of Current Research in Clinical Cancer
Vol 5 Issue 1, 2025 | İrem Sarıcanbaz
An Overview of Targeted Therapy Applications in Cancer Treatment
Asian Journal of Current Research in Clinical Cancer
Vol 5 Issue 1, 2025 | Yeuan Ting Lee
Evaluating the Effects of Plasma Irradiation and Stevia on Gene Expression and Immune Responses in HepG2 Cells
Asian Journal of Current Research in Clinical Cancer
Vol 5 Issue 1, 2025 | Fatma Hussein Abdelwahab
Long-Term Survival Outcomes of Colorectal Cancer Survivors: An In-Depth Exploration
Asian Journal of Current Research in Clinical Cancer
Vol 5 Issue 1, 2025 | Zhaobei Cai
Superficial Basal Cell Carcinoma of the Nipple Mimicking Paget’s Disease of the Breast
Asian Journal of Current Research in Clinical Cancer
Vol 5 Issue 1, 2025 | Ahmed Samaouel Chehad
Exploring the Radiosensitizing Effects of Tolmetin in Radiotherapy for Human Clonal Cancer Cells
Asian Journal of Current Research in Clinical Cancer
Vol 5 Issue 1, 2025 | Deep Kwatra

About GalaxyPub

Find out more

Our esteemed publisher is committed to advancing medical knowledge through rigorous research dissemination. We exclusively accept submissions related to the field of medicine.

Our journals provide a platform for clinicians, researchers, and scholars to share groundbreaking discoveries, clinical insights, and evidence-based practices. By maintaining this specialized focus, we ensure that their publications contribute significantly to the advancement of healthcare worldwide.