Despite significant advances in heart transplant treatment, transplant rejection remains a significant challenge. Lovastatin, a statin medication with intriguing immunomodulatory effects, has received attention as a potential treatment for heart transplant rejection. All of the studies show that lovastatin can affect T-cell activation, reduce acute rejection events, and preserve graft function. These results provide encouraging directions for the use of lovastatin to improve patient outcomes and
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In patients with transfusion-dependent thalassemia (TDT), adherence to iron chelation therapy (ICT) is essential for avoiding iron excess consequences and preserving HRQoL. The present research sought to assess the relationship between adherence and HRQoL in TDT patients from Malaysia. A cross-sectional study was conducted among TDT patients aged 18 years and above at Hospital Ampang, Selangor. The adherence and the HRQoL (SF-36) were measured utilizing validated tools. Correlation analyses were
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Written by Andrei Nicolae Csep
Published on Vol 4, 2024
The likelihood of chronic illnesses and concurrent usage of several pharmaceuticals has grown due to the aging population and longer life expectancy, which might result in negative drug interactions and responses. This review research was conducted to look into the elderly’s polypharmacy management strategies, as there is no comprehensive study on the subject. Polypharmacy, the elderly, and prevalence were searched in the PubMed, Science Direct, Scopus, Google Scholar, Ovid, Magiran, and Sid dat
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The more recent generation of anti-retroviral medication (ART) has completely changed the way that HIV infections are treated. Tenofovir with lamivudine (NRTI) and one NNRT, efavirenz, make up the first-line ART. One side effect that is cause for concern is the renal tubular dysfunction linked to tenofovir. The purpose of this study was to compare the incidence of nephrotoxicity from tenofovir-based regimens to those that were not TLE-based. 50 individuals between the ages of 18 and 60 years wh
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The purpose of the present investigation was to assess the pattern of distributing antibiotics without an order at a Baghdad community pharmacy, as well as to better comprehend the variables that influence antibiotic dispensing without authorization. A cross-sectional survey of community pharmacists was conducted to explain antibiotic distribution practices in community pharmacies. To collect the requisite sample, the convenience sampling approach was used at a Baghdad community pharmacy. The pa
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Written by Maha Mahfouz Bakhuraysah
Published on Vol 4, 2024
Several regulatory bodies throughout the world have produced and approved several COVID-19 vaccines for use in emergencies. In addition to providing a centralised database of suspected adverse reactions and safety profiles for these vaccinations, the aim is to compare the safety and side effects of approved COVID-19 vaccines in Saudi Arabia. As part of this cross-sectional study, an online questionnaire was used to survey 633 vaccinated Saudi Arabian citizens. Their ages ranged from 15 to 85 yea
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Written by Maria Pia Ferraz
Published on Vol 4, 2024
In oral and maxillofacial surgery, a small number of drugs are used to treat wounds, pain, infection, and healing. The ingredients, uses, and effects of these drugs on oral tissues are not well understood, despite their widespread usage. The purpose of this study is to identify the ideal material for the treatment of intraoral wounds. Among the materials that can be used successfully are Alvogyl, Carnoy’s solution (CS), bismuth iodoform paraffin paste (BIPP), zinc oxide eugenol (ZOE), and Whiteh
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Written by Viviana Hodoșan
Published on Vol 4, 2024
Intensive care units (ICUs) are the primary target for antibiotic consumption monitoring due to their high antibiotic usage. Antimicrobial resistance (AMR) is a major global public health concern. We conducted a five-year, monocentric, retrospective, and observational study to assess the use and cost of antibiotics in the intensive care units at the Oradea County Emergency Clinical Hospital in Romania. The amount was expressed in DDD/100 patient days, and the prescription antibiotic’s cost was i
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There is no written advice tool for the use of subcutaneous anticoagulants in patients with COVID-19, so this study aimed to develop and validate one. A prospective cohort study was conducted with patients and expert panels, and hospital chemists used the content validity index (I-CVI), scale-level-CVI (S-CVI), and universal acceptance (UA) to validate the tool. The item acceptance index (IAI) and universal acceptance (UA) were used to assess the patients’ face validity. The mean age of hospital
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