Written by Philippe Lefevre
Published on Vol 5 , 2025
3D printing represents a cutting-edge approach for fabricating three-dimensional structures through the layer-by-layer deposition of materials guided by computer software. Its integration into the pharmaceutical field is driven by its transformative capacity to produce customized dosage forms tailored to individual patient requirements, as it allows for the fabrication of products in diverse sizes and geometries. A key benefit of personalized 3D-printed tablets lies in their ability to incorpora
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Written by Henrik Lindstrom
Published on Vol 5 , 2025
Adverse drug interactions remain a major concern in hospital care, emphasizing the pivotal role of pharmacists in mitigating associated risks. This study explored the understanding, perspectives, and practical approaches of hospital pharmacists in South Sulawesi Province, Indonesia, toward clinically important drug interactions. A cross-sectional survey was conducted online from November 2023 to January 2024, targeting hospital pharmacists. Out of 312 participants, 38.8% showed limited knowledge
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The Italian higher education system is actively updating the Master of Pharmacy (MPharm) curriculum to address evolving healthcare demands post-COVID-19 and to emphasize clinical competencies. Investigating the experiences of Italian pharmacists who have moved to Great Britain (GB) can provide important insights into the applicability of skills and knowledge acquired through Italian pharmacy education. This study aimed to explore the perspectives of Italian pharmacists practicing in GB concernin
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This research examines the long-term toxicity of nano-formulated Bischofia javanica leaves, a medicinal plant widely used in Indonesia, following OECD guideline 452. Mice were administered four different doses (2, 4, 6, and 8 g/kg body weight) of the nano-formulated extract for 60 days, while the control group received only water. On the 61st day, animals were euthanized for the collection of blood and tissue samples for biochemical, hematological, and histopathological evaluation. Data analysis
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The present study explored the anti-breast cancer properties of novel pyrazoline-substituted benzenesulfonamides (6–10) through computational and laboratory approaches. Molecular docking analyses using the GOLD suite were performed on the human estrogen receptor and the PARP1 antagonist crystal structure, with tamoxifen serving as the reference compound, yielding comparable binding results. In vitro evaluation on MCF-7 and MDA-MB-468 breast cancer cell lines revealed that these compounds exerted
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Written by Saki Kobayashi
Published on Vol 5 , 2025
This study aimed to examine adverse drug reaction (ADR) reports documented in the scientific literature that occurred during or after the administration of kinase inhibitors in patients treated for rheumatologic disorders, focusing on identifying their nature, prevalence, and severity. A systematic search was carried out in the MEDLINE and PubMed databases covering the period from January 2005 to May 2022. Out of 291 retrieved publications, only those meeting the inclusion criteria were selected
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Older adults taking multiple medications are at increased risk for complications such as adverse drug reactions, medication errors, and harmful drug interactions. This study investigated the occurrence of potentially inappropriate prescriptions (PIP) in a community pharmacy in Trujillo, Peru, applying the STOPP/START criteria (Screening Tool of Older Persons’ Prescriptions/Screening Tool to Alert Doctors to Right Treatment). A total of 158 individuals participated, with the majority aged 65–69 y
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In patients with stage IV colorectal cancer, removing the primary tumor may prevent future tumor-related complications, enhance quality of life, and reduce the likelihood of emergency colostomies. Laparoscopic surgery offers a minimally invasive alternative that can potentially lower perioperative risks in this high-risk patient group. This study evaluates short-term surgical outcomes in 17 patients with stage IV colorectal cancer who had unresectable liver metastases and/or pulmonary or periton
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Written by Antonio Conti
Published on Vol 5 , 2025
Tadalafil (TDA), a Biopharmaceutics Classification System (BCS) class II drug, exhibits poor aqueous solubility but high permeability. This study focused on enhancing the bioavailability of poorly soluble TDA through the development of intranasal nanocrystals (NCs). TDA NCs stabilized with polyvinyl alcohol (PVA) demonstrated the smallest particle size and optimal solubility. Formulation F11 measured 196 nm in size, with a polydispersity index (PDI) of 0.21 and a zeta potential of -11.20, showin
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Analyzing the competitive landscape of the pharmaceutical market is a key aspect of assessing the drug supply system. This study aims to examine the changes in concentration levels within the wholesale segment of a regional pharmaceutical market. Data on the market shares of major distributors were collected and compiled from 461 contracts executed for the supply of pharmaceutical products in the selected region. The Herfindahl-Hirschman Index (HHIn) was employed to evaluate the competitiveness
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Source-separated human urine has become an attractive nutrient resource due to its high levels of nitrogen and phosphorus, which can be repurposed as fertilizer. Nevertheless, it also contains contaminants such as pharmaceuticals and steroid hormones, whose elimination is vital to prevent adverse environmental and health effects. In this study, a double-chamber microbial fuel cell (MFC) was employed to explore the degradation of pharmaceuticals. Urine was intentionally spiked with four compounds
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Customer satisfaction serves as a key indicator of success in pharmaceutical services and is closely linked to trust in the pharmacy. Satisfaction with pharmaceutical services plays a crucial role in encouraging patient adherence to healthcare recommendations. This study aims to explore the relationship between customer satisfaction and trust in pharmacies. Employing a quantitative approach with a cross-sectional survey design, the research was carried out in June 2023 with a sample of 252 commu
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In July 2020, the National Medical Products Administration and the National Health Commission of China approved the 2020 edition of the Chinese Pharmacopoeia, which was officially enacted on December 30, 2020. The general chapters serve as the foundation for drug standards, detailing common testing procedures and implementation guidelines. Compared to previous editions, the 2020 version demonstrates notable enhancements, emphasizing scientific validity, broad applicability, practical operability
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This review presents a comprehensive overview of Ipomoea batatas L., belonging to the Ipomoea genus, highlighting its traditional uses, nutritional profile, phytochemical composition, pharmacological activities, and toxicity evaluations. Information was gathered from scientific databases and online search engines. Sweet potatoes are traditionally utilized in many countries as sources of dietary fiber, remedies for allergies, and energy boosters, particularly in the management of diabetes mellitu
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Hypertension, a major silent threat to human health, is marked by persistently elevated blood pressure. Although conventional pharmacological treatments have shown effectiveness, they are often limited by high costs and adverse effects. Recently, natural products have emerged as potential alternatives for managing hypertension. This study explored the antihypertensive potential of Allium schoenoprasum using network pharmacology and molecular docking approaches. Bioactive compounds and relevant t
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From a regulatory standpoint, evaluating the consistency of drug quality requires consideration of the various manufacturing processes for the same product. This study proposes a strategy grounded in quality by design (QbD) for assessing pharmaceutical quality at the population level. Initially, a descriptive analysis framework based on QbD principles was established to define processes through critical evaluation attributes (CEAs). Subsequently, a quantitative analysis approach, employing an en
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This pilot study set out to examine, for the first time in Bulgaria, how effectively the EU(7)-PIM List can identify potentially inappropriate medications (PIMs) prescribed to older adults. Drug-related complications are well-documented contributors to increased rates of illness, death, and healthcare use. Although earlier Bulgarian research has discussed methods for detecting such medications, the application of the EU(7)-PIM List has not been thoroughly explored and requires further evaluation
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At the onset of the twenty-first century, obesity has emerged as a major global health concern due to its widespread prevalence in modern populations. It is a metabolic disorder characterized by excessive accumulation of adipose tissue, primarily driven by increased caloric intake, reduced energy expenditure, and dysregulation of hunger signals. Obesity is a chronic systemic condition that contributes to numerous health complications, with the most common being type 2 diabetes mellitus, arterial
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