Written by Miftakhutdinova Elena
Published on Vol 1 , 2021
This paper aimed to create a method for turning fowl flesh that has been enhanced with lithium into a paste. The research achieved the best method for chopping minced meat for paste, which provides excellent organoleptic and physicochemical properties and low microbiological contamination. The process of rearing birds and supplementing their diet with fortified food raw materials (poultry meat) with a crucial element (lithium) has a bigger impact. The safety of using poultry paste enhanced with
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Written by Angelique Welman
Published on Vol 1 , 2021
The virus that creates COVID-19, SARS-CoV-2, is highly contagious and typically replicates in the upper and lower respiratory tract to cause atypical pneumonia in humans. The gastrointestinal and cardiovascular tissues that contain its primary binding receptor, ACE2, may also be infected. A variety of therapeutic approaches have been investigated and modified to reduce the potentially dangerous clinical consequences of the COVID-19 pandemic. However, there isn't a proven cure for this illnes
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Written by Mustafa Mohammed Al Brahim
Published on Vol 1 , 2021
Multiple sclerosis, an autoimmune demyelinating illness, is a common disease in young adults. Low vitamin D levels are a risk factor associated with multiple sclerosis. Numerous regulatory functions, particularly those related to the immune system, depend on vitamin D. Following the discovery of seasonal and geographic variations in the incidence of multiple sclerosis worldwide, it was suggested 50 years ago that vitamin D may play a role in the risk of developing and relapsing multiple sclerosi
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Written by Zeb-un-Nisa Zeb-un-Nisa
Published on Vol 1 , 2021
Using hydrophilic Methocel® K4M, the current study sought to design a sustained-releasing and acting formulation of Domperidone, an antiemetic medication used to treat nausea and vomiting, with a typical dosage that is administered twice or three times per day. The sustained-release formulation was made using various ratios of K4M, and its quality and stability were assessed. The optimized formulation was chosen for dissolution studies and similarity profiles after pre-compression and post-compr
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Written by Mariana Ganea
Published on Vol 1 , 2021
One of the critical components of the pharmaceutical industry is the capacity of pharmaceutical forms to remain stable over time and maintain their quality under different storage and transportation circumstances. Therefore, the amount of active components in the pharmaceutical form is evaluated following the ICHQ1A standards of the European Pharmacopoeia to ascertain the validity of the pharmaceutical product. This paper aims to investigate the stability of 100 mg ketoprofen tablets. Short-term
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Written by Prashant Lakshaman Pingale
Published on Vol 1 , 2021
Antipsychotic medications can help manage the symptoms of schizophrenia. Several demographic and scientific elements have the potential to influence the choice of unusual neuroleptic drugs. Bipolar disorder and schizophrenia can be treated with quetiapine fumarate. When making tablets and hard-shell capsules, disintegrating agents are often utilized ingredients. The primary goal of this study was to develop a dependable immediate-release tablet formulation of the antipsychotic quetiapine. Tablet
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Written by Savannah Hayes
Published on Vol 1 , 2021
Chronic bronchitis (CB) is a long-standing inflammatory airway disorder with a high global burden and limited treatment success. In recent years, the combined use of traditional Chinese medicine (TCM) with standard medical care has been increasingly adopted for CB and has shown encouraging therapeutic potential. A multicenter randomized controlled trial directed by the China–Japan Friendship Hospital (Beijing, China) recruited 300 individuals with CB aged 18–75 years. Participants were allocated
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Tailored administration of adjuvant chemotherapy (ACT) enhances treatment efficiency and postoperative well-being in individuals with stage II–III colorectal cancer (CRC). Nonetheless, reliable biomarkers capable of forecasting responses to 5-fluorouracil (5-FU) and oxaliplatin remain insufficient. Three separate cohorts comprising 1676 stage II–III surgical cases were assessed to determine the prognostic value of 12 inflammatory markers. Using multivariable Cox modeling, we generated a novel Ch
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This investigation assessed the practicality and tolerability of arterial infusion chemotherapy embolization (AICE) for patients with recurrent or metastatic soft tissue sarcoma (STS), and examined prognostic indicators that could support more personalized treatment planning. This retrospective analysis enrolled 113 individuals with recurrent/metastatic STS who underwent AICE at the Fifth Medical Center of the PLA General Hospital. Key endpoints included progression-free survival (PFS) and overa
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Written by Miguel Santos
Published on Vol 1 , 2021
Immunotherapy has become a foundational component of first-line management for advanced gastric and gastroesophageal junction cancer (G/GEJC). After disease progression on such regimens, however, the optimal second-line approach remains uncertain. Because cadonilimab has demonstrated strong activity in initial treatment, this real-world analysis explored its use with chemotherapy in the second-line setting. We performed a retrospective review at a single institution involving patients with advan
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Remimazolam is a newer hypnotic that generally preserves cardiovascular stability better than propofol during general anesthesia, a benefit that appears pronounced in older adults. Despite this, the extent to which remimazolam lowers blood pressure in a dose-related manner has not been formally quantified in this age group. We re-examined information from 432 individuals aged ≥ 65 years enrolled in a randomized trial comparing remimazolam with propofol for elective gastrectomy. Remimazolam was i
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This work aimed to clarify how MLN4924 influences acute myeloid leukemia (AML) biology, focusing on its ability to regulate TRIM58 promoter methylation and the downstream molecular events. RT-qPCR and Western blotting were applied to quantify transcript and protein levels, while methylation-sensitive restriction enzyme–qPCR assessed DNA methylation status. RNA sequencing was used to screen for lncRNAs with altered expression. Subcellular fractionation followed by PCR identified transcript locali
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Written by Barbara Zielinska
Published on Vol 1 , 2021
Fospropofol disodium for injection (FospropofolFP) is a recently introduced, water-soluble precursor of propofol used for procedural sedation and induction of anesthesia. This prospective cohort investigation assessed how hepatic dysfunction affects the pharmacokinetics and safety of FospropofolFP during general anesthesia, comparing impaired subjects with matched healthy individuals. A total of 23 participants were recruited and grouped by liver status: normal hepatic function (n = 10), moderat
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Written by Samuel Mensah
Published on Vol 1 , 2021
The need for effective targeted agents against hepatocellular carcinoma remains pressing. This investigation focused on designing and examining a new panel of triazole–urea hybrid molecules for potential anticancer activity. A collection of urea derivatives containing terminal alkynes was generated using a combined assembly and modification route. These intermediates were subsequently transformed through Click chemistry to afford novel triazole–urea hybrids (3a–3e, 5a–5e, 7a–7e). Their growth-in
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