The World Health Organization (WHO) reports that between 9% and 45% of people are affected by musculoskeletal disorders, and around 3% of the population may become disabled due to bone and joint diseases, and almost all of these people experience significant pain. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed to alleviate this pain. This article reviews the use of NSAIDs in the management of chronic inflammatory rheumatic diseases, as well as their effects on the body. A study of patients with severe psoriatic arthritis showed that prevention with methotrexate resulted in fewer cardiovascular events compared to other prevention methods, such as traditional treatments, phototherapy, and climatotherapy. Furthermore, this article suggests that inhibitors may play a protective role against tumor necrosis. The prevention approach appears to have a significant impact on reducing the incidence of cardiovascular disease in patients with severe psoriatic arthritis, emphasizing the need for further research to evaluate the cardiovascular safety and efficacy of systemic therapies.
