The novel coronavirus primarily spreads through airborne droplets and contaminated surfaces. To limit transmission, the widespread use of face masks and gloves has become a daily practice, resulting in a significant rise in environmental waste. Improper disposal of these items in public spaces may further facilitate virus transmission. Despite this growing concern, studies exploring public perceptions of managing pandemic-related masks and gloves remain scarce. This study investigates public awareness, attitudes, and practices concerning the disposal of gloves and masks during the COVID-19 pandemic in Saudi Arabia. The results indicate that 74% of participants are knowledgeable about correct disposal practices, and 76% demonstrate positive attitudes toward waste management. Gender was significantly associated with adherence to biomedical waste regulations (r = 0.169, p = 0.0001) and with recognizing community responsibility in proper COVID-19 waste disposal (r = 0.158, p = 0.0001). Most participants were aware of existing regulations governing biomedical waste collection and disposal. Furthermore, public perception of the effectiveness of municipal measures to prevent virus spread showed a significant positive correlation with awareness levels (r = 0.279, p = 0.0001). Overall, the findings emphasize that proper management of infectious waste is essential to safeguard communities from the risks associated with improper disposal during the COVID-19 pandemic.